[21954-69-8] · C5H13NO2S · Methyl Diethylamidosulfite · (MW 151.26)
(conversion of carboxylic acids to N,N-diethylamides2)
Physical Data: bp 73-74 °C/10 mmHg.
Solubility: sol diethyl ether.
Form Supplied in: clear oil.
Analysis of Reagent Purity: titration with iodine.
Purification: vacuum distillation.2
Handling, Storage, and Precautions: prolonged heating at atmospheric pressure causes decomposition with evolution of sulfur dioxide.
This reagent reacts with primary and secondary carboxylic acids in the presence of pyridine to give N,N-diethylamides (eq 1). The reaction is typically run at rt and requires a long reaction time (several days). In general, tertiary acids and a-amino carboxylic acids do not react.2,3
Brian A. Roden
Abbott Laboratories, North Chicago, IL, USA